Prostaglandin E2 in Remote Control of Myocardial Remodeling
نویسندگان
چکیده
منابع مشابه
Prostaglandin E2 in remote control of myocardial remodeling.
Despite the advance in treatment of acute myocardial infarction (MI) with timely reperfusion of ischemic myocardium, coronary artery disease remains a leading cause of morbidity and mortality worldwide. In patients who have survived acute MI, the heart undergoes a remodeling process characterized by changing in size, shape, structure, and function. The progressive ventricular dilation, wall thi...
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BACKGROUND Pharmacological inhibition of cyclooxygenase-2 increases the risk of myocardial infarction (MI) and stroke. Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1), encoded by the Ptges gene, functions downstream from cyclooxygenase-2 in the inducible PGE(2) biosynthetic pathway. We caused acute MI in Ptges(+/+) and Ptges(-/-) mice to define the role of mPGES-1 in cardiac ischemic in...
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The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No significant changes in the levels of PGE2 or its metabolites were found on the maternal side. Bacteria...
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Endometriosis is a leading cause of infertility in women of reproductive age. It involves the occurrence of endometrial tissue outside the uterine endometrium, mainly in the peritoneal cavity. Prostaglandin E(2) is up regulated in the peritoneal cavity in endometriosis and is produced by macrophages and ectopic endometrial cells. This prostaglandin is involved in the pathophysiology of the dise...
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We studied the effects of prortaglandin PGE,, PGE,, and prostacyclin (PGIa) on collateral blood flow (CBF) and myocardial infarct size in conscious dogs. Beginning 5 minutes after acute permanent occlusion of the mid left circumflex coronary artery, 6-hour infusions of PGEi (0.6 ag/kg per min in 150 saline, 13 dogs), PGE, (0.7 /ig/kg per min in 150 ml saline, 11 dogs), PGI, (0.5 /ig/kg per min ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2012
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.110726